Dailymed voriconazole injection, powder, for solution. See full prescribing information for instructions on oral administration of vfend in adults and pediatric individuals 2 years of age and older. Vfend voriconazole is an antifungal medication used to treat infections caused by yeast or other types of fungus. Voriconazole is a broad spectrum, triazole antifungal agent and is indicated in adults and children aged 2 years and above as follows. Voriconazole, sold under the brand name vfend among others, is an antifungal medication used to treat a number of fungal infections. There is no information regarding crosssensitivity between voriconazole and other azole antifungal agents. Dec 01, 2018 voriconazole is contraindicated in patients with known hypersensitivity to voriconazole or its excipients. May 09, 2019 our vfend voriconazole side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Patient information vfend veefend voriconazole tablets, for oral use vfend veefend voriconazole for oral suspension vfend veefend voriconazole for injection, for intravenous use. Voriconazole is a newgeneration triazole antifungal agent with potent activity against a wide range of clinically significant pathogens, including aspergillus and candida, as well as some less common fungal pathogens. Comparison of itraconazole, voriconazole, and posaconazole. Help drugs pi website grow, register now and become a. Voriconazole is a triazole antifungal medication approved for the treatment of aspergillosis in transplant patients and is most often used in lung transplant patients.
Take oral voriconazole tablets or liquid at least 1 hour before or 1 hour after eating a meal shake the liquid before you measure a dose. Full prescribing information 1 indications and usage voriconazole is indicated for use in patients 12 years of age and older in the treatment of the following fungal infections. See full prescribing information for instructions on reconstitution of lyophilized powder for intravenous use and important administration instructions 2. Voriconazole can increase sirolimus levels from 7 to 11fold, 6 and posaconazole can increase sirolimus levels about 9fold. In order to provide you with relevant and meaningful content we need to know more about you. Vfend voriconazole fdaapproved patient labeling pfizer. In a multipledose trial, voriconazole 18 mgkg or water was administered orally to 6 and 4 birds, respectively, every 8 hours for 11 days beginning day 0. No dose adjustment is necessary for elderly patients. A fairly newly described side effect of longterm voriconazole use is periostitis. Read the patient information that comes with vfend before you start taking it and each time you get a refill. These highlights do not include all the information needed to use vfend safely and effectively. Vfend voriconazole highlights pfizer medical information.
A fairly newly described side effect of longterm voriconazole use is. Decrease dose in patients with hepatic impairment 2. Highlights of prescribing information these highlights do not. Grapefruit juice may also increase plasma concentrations of ixempra and should be avoided. Help drugs pi website grow, register now and become a recognized active member by adding new content. Myers, in kidney transplantation principles and practice eighth edition, 2019.
There was a small number of cases of cultureproven disease due to species of aspergillus other than a. See full prescribing information for voriconazole for oral suspension. Caution should be used when prescribing vfend to patients with hypersensitivity to other azoles. Please like drugs pis facebook page for even more updates. Highlights of prescribing information safely and effectively. This medicine is available only with a doctors prescription. Voriconazole for oral suspension, 40 mgml initial u. Voriconazole tablets ordering information 50 mg x 30 ndc 5976209341 sales code f000035506 unit of sale bottle units per case 48 shipping case outer dimensions lxwxh 12. Voriconazole is contraindicated in patients with known hypersensitivity to voriconazole or its excipients. Noxafil posaconazole injection, for intravenous use noxafil posaconazole delayedrelease tablets, for oral use noxafil posaconazole oral suspension. Cisapride, astemizole, cisapride, pimozide, or quinidine.
Vfend dosage and monitor for adverse reactions or lack of efficacy 4, 7. Voriconazole fda prescribing information, side effects. Vfend voriconazole tablets, for oral use vfend voriconazole for oral suspension vfend voriconazole for injection, for intravenous use initial u. Food and drug administration fda for the treatment of certain fungal infections, such as esophageal candidiasis. Voriconazole fda prescribing information, side effects and uses.
Full prescribing information 1 indications and usage voriconazole tablets are indicated for use in patients 12 years of age and older in the treatment of the following fungal infections. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Caution should be used when prescribing voriconazole for injection to patients with hypersensitivity to other azoles. Generic formulations of voriconazole tablets are also available.
Not recommended for use during pregnancy because of substantially lower exposures of cobicistat and elvitegravir during pregnancy. Voriconazole is an antifungal medication used primarily for the treatment of candida and aspergillus infections. Voriconazole is an antifungal prescription medicine approved by the u. Voriconazole is designated chemically as 2r,3s22,4difluorophenyl35. These highlights do not include all the information needed to use rayaldee safely and effectively.
Highlights of prescribing information these highlights do not include all the information needed to use noxafil safely and effectively. Please choose the category that best describes you. Sandoz inc voriconazole voriconazole injection, powder. Arizona medicaid revision log see important reminder at the end of this policy for important regulatory and legal information. The pharmacokinetics of orally administered voriconazole. Voriconazole may also be used for purposes not listed in. Efavirenz decreases voriconazole levels and voriconazole increases efavirenz levels. Vfend voriconazole dosing, indications, interactions.
Supplied as 50 mg and 200 mg tablets in bottles of 30. The voriconazole prescribing information defines patients with impaired renal function as having a creatinine level 2. Patients and their carers should be told how to recognise symptoms of liver disorder, and advised to seek immediate medical attention if symptoms. Voriconazole comes as a tablet and a suspension liquid to take by mouth. Voriconazole is used to treat infections caused by yeast or other types of fungus. Voriconazole induced photosensitivity results in a sunburnlike erythema on sunexposed sites. Full prescribing information 1 indications and usage therapy with lipidaltering agents should be only one component of multiple risk factor intervention in. Voriconazole is indicated for the treatment of invasive aspergillosis. Vfend voriconazole, a triazole antifungal agent, is available as a lyophilized powder for solution for intravenous infusion, filmcoated tablets for oral administration, and as a powder for oral suspension.
In clinical trials, the majority of isolates recovered were aspergillus fumigatus. Voriconazole side effects, dosage, interactions drugs. One of the wellestablished side effects of voriconazole is photosensitivity. Since its approval in 2002, voriconazole has changed the approach to the management of invasive fungal diseases. Based on pharmacokinetic studies, if a strong cyp3a4 inhibitor must be coadministered. This dose may need to be adjusted by your doctor to meet your needs. Follow the directions on your prescription label carefully, and ask your doctor.
Treatment should be initiated with intravenous regimen, and oral regimen should be considered only after there is a significant clinical improvement. Aug 01, 2019 itraconazole is contraindicated for patients who have shown hypersensitivity to itraconazole. Highlights of prescribing information these highlights do not include all the information needed to use voriconazole for oral suspension safely and effectively. Vfend, innvoriconazole european medicines agency europa eu. Flavours of oral liquid formulations may include orange. Vfend voriconazole iv, tablets and suspension label fda. For more information on drug interactions and cytochrome p450, please refer.
Consumer medicine information cmi about voriconazole apotex powder for injection voriconazole intended for persons living in australia. Highlights of prescribing information infusionrelated. Itraconazole fda prescribing information, side effects and uses. Highlights of prescribing information these highlights do not include all the information needed to use vfend safely and effectively. See 17 for patient counseling information and fdaapproved patient labeling. Initially 200 mg every 12 hours for 2 doses, then 100 mg every 12 hours, increased if necessary to 150 mg every 12 hours. This informationincluding product informationis intended only for residents of the united states. Voriconazole apotex powder for injection voriconazole. Viibryd vilazodone hydrochloride tablets, for oral use initial u. It is usually taken every 12 hours on an empty stomach, at least 1 hour before or 1 hour after a meal.
Toxicity in hepatic impairment ixempra ixabepilone in combination with capecitabine is contraindicated in patients with ast or alt 2. To help you remember to take voriconazole, take it at around the same times every day. Voriconazole tablets are indicated in adults and pediatric patients 2 years of age and older for the treatment of invasive apergillosis ia. Antifungal agents cresemba isavuconazonium, noxafil. This is not a complete list of side effects and others may occur. Voriconazole is a triazole antifungal with enhanced activity against a broad spectrum of fungal pathogens, including aspergillus and candida species 11, 26. This product should only be used under the supervision of a doctor.
Jan 28, 2019 therefore, concomitant use of these agents is contraindicated as instructed in the prescribing information. Voriconazole vfend, pfizer ireland pharmaceuticals, ringaskiddy, ireland is a triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Rayaldee calcifediol extendedrelease capsules, for oral use. A variety of dosing regimens of 800 mgday were given in two to four divided doses during clinical studies for treatment of certain refractory invasive fungal infections in. See full prescribing information for instructions on reconstitution of. Administration of voriconazole in patients with renal. Esophageal candidiasis is an infection of the esophagus.
Do not take two doses at one time call your doctor for instructions if you miss a dose of injectable voriconazole what happens if i. It can be taken by mouth or used by injection into a vein common side effects include vision problems, nausea, abdominal. This information including product information is intended only for residents of the united states. Prescribers will be aware of the importance of considering the potential for interactions when they prescribing new treatments. Caution should be used when prescribing itraconazole to patients with hypersensitivity to other azoles. In fact, several population pharmacokinetic studies 15, 16, 19, 25 did not enroll patients who received agents that substantially affect voriconazole exposure. Use the dosing syringe provided, or use a medicine dosemeasuring device not a kitchen spoon. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by scedosporium or fusarium. Esophageal candidiasis is an opportunistic infection oi of hiv. The products discussed herein may have different labeling in different countries.
Voriconazole may increase plasma levels of these drugs and result in qt prolongation. In healthy subjects, the absorption of voriconazole is not. When treatment with voriconazole is stopped, the initial dosage of. Voriconazole interacts with a variety of drugs due to inhibition of cytochrome p450 enzyme system. Follow all directions on your prescription label and read all medication guides or instruction sheets. Immunosuppressant interactions azoles and immunosuppressants also interact. It is structurally related to fluconazole, with the major difference being the substitution of a fluoropyrimidine grouping in place of a triazole moiety 5, 6. Call your doctor for medical advice about side effects. Description voriconazole vfend is an azole antifungal drug.